Dr. Tan Wen Nee

Tan Wen Nee 2  

Dr. Tan Wen Nee
Phone   : 04-6534563
Fax       : 04-6576000
Email   : tanwn@usm.my

Organic Chemistry, Natural Product Chemistry



Academic Qualifications:

  • Ph.D. (Natural Product) 2014, Universiti Sains Malaysia
  • B.Sc. (Chemistry) 2009, Universiti Sains Malaysia


Key Research Area: 

  • Isolation and characterization of natural products
  • Bioactivity studies of natural products
  • Flavour and fragrance
  • Application of natural products in biomedical related field
  • Metabolomics study


Journal Articles: 

  1. Wen Nee Tan, Keng Chong Wong, Melati Khairuddean, Madhukar Hemamalini and Hoong-Kun Fun. (2011). Absolute configuration of 3β-acetoxyolean-11,12-aziridin-28,13-β-olide. Acta Crystallographica Section E, E67, o1220.
  1. Wen-Nee Tan, Keng-Chong Wong, Melati Khairuddean, Ibrahim M. Eldeen, Mohd. Zaini Asmawi and Baharuddin Sulaiman. (2013). Volatile constituents of the fruit of Garcinia atroviridis and their antibacterial and anti-inflammatory activities. Flavour and Fragrance Journal, 28, 2-9.
  1. Wen-Nee Tan, Melati Khairuddean, Keng-Chong Wong, Kooi-Yeong Khaw and Murugaiyah Vikneswaran. (2014). New cholinesterase inhibitors from Garcinia atroviridis. Fitoterapia, 97, 261-267.
  1. W. Y. Tong, J. Nurul Zaadah, Nurhaida, W. N. Tan, K. Melati, Z. Latiffah and I. Darah. (2014). Antimicrobial activity of Phomopsis sp. ED2 residing in medicinal plant Orthosiphon stamineus Benth. Annual Research & Review in Biology, 4(9), 1490-1501.
  1. Ibrahim M.S. Eldeen, Habsah Mohamed, Wen-Nee Tan, Julius Y.F. Siong, Yosie Andriani and Tengku S. Tengku-Muhammad. (2016). Cyclooxygenase, 5-lipoxygenase and acetylcholinesterase inhibitory effects of fractions containing, α-guaiene and oil isolated from the root of Xylocarpus moluccensis. Research Journal of Medicinal Plants, 10(4), 286-294.
  1. Wen-Nee Tan, Melati Khairuddean, Keng-Chong Wong, Woei-Yenn Tong and Darah Ibrahim. (2016). Antioxidant compounds from the stem bark of Garcinia atroviridis. Journal of Asian Natural Products Research, 18(8), 804-811.
  1. Tong Woei Yenn, Leong Chean Ring, Tan Wen-Nee, Melati Khairuddean, Latiffah Zakaria and Darah Ibrahim. (2017). Endophytic Diaporthe sp. ED2 produces a novel anti-candidal ketone derivative. Journal of Microbiology and Biotechnology, 27(6), 1065-1070.
  1. Chean-Ring Leong, Muhammad Afif Kamarul Azizi, Md Abu Taher, Suzana Wahidin, Kok-Chang Lee, Wen-Nee Tan and Woei-Yenn Tong. (2017). Anthocyanins from Clitoria ternatea attenuate food-borne Penicillium expansum and its potential application as food biopreservative. Natural Product Sciences, 23(2), 125-131.
  1. Nur Amiera Syuhada Binti Rozman, Nurhanis Syafiqah Binti Mohd Nor Hamin, Leong Chean Ring, Tan Wen Nee, Mahfuzah Binti Mustapha and Tong Woei Yenn. (2017). Antimicrobial efficacy of Penicillium amestolkiae elv609 extract treated cotton fabric for diabetic wound care. Mycobiology, 45(3), 178-183.
  1. Tong Woei Yenn, Darah Ibrahim, Lee Kok Chang, Syarifah Ab Rashid, Leong Chean Ring, Tan Wen Nee and Muhamad Izham bin Muhamad Noor. (2017). Antimicrobial efficacy of endophytic Penicillium purpurogenum ED76 against clinical pathogens and its possible mode of action. Korean Journal of Microbiology, 53(3), 193-199.
  1. Tong Woei Yenn, Muhammad Arslan Khan, Nur Amiera Syuhada, Leong Chean Ring, Darah Ibrahim and Wen-Nee Tan. (2017). Stigmasterol: An adjuvant for beta lactam antibiotics against beta-lactamase positive clinical isolates. Steroids, 128, 68-71.
  1. Wen-Nee Tan, Jia-Qin Lim, Fatin Afiqah, Nik Nur Syazni Nik Mohamed Kamal, Fatin Athirah Abdul Aziz, Woei-Yenn Tong, Chean-Ring Leong and Jun-Wei Lim. (2018). Chemical composition and cytotoxic activity of Garcinia atroviridis Griff. ex T. Anders. essential oils in combination with tamoxifen. Natural Product Research, 32(7), 854-858.
  1. Woei Yenn Tong, Ahmad Yassin Kamari bin Abdullah, Nur Amiera Syuhada binti Rozman, Muhamad Izul Aimin bin Wahid, Md. Sohrab Hossain, Leong Chean Ring, Yusriah Lazim and Wen-Nee Tan. (2018). Antimicrobial wound dressing film utilizing cellulose nanocrystal as drug delivery system for curcumin. Cellulose, 25, 631-638.
  1. Chean Ring Leong, Adib Arifah Binti Mansur, Syarifah Abdul Rashid, Swee Ngim Ang, Wen-Nee Tan, Woei Yenn Tong and Darah Ibrahim. (2018). Antimicrobial activity of Aspergillus sp. IBRL MP15 CCL, an endophytic fungus isolated from Swietenia macrophylla leaf against human pathogens. Malaysian Journal of Microbiology, 14(1), 49-54.
  1. Tong Woei Yenn, Leong Chean Ring, Khairul Azly Zahan, Muhammad Sharir Abdul Rahman, Wen-Nee Tan and Bintul Jauza’ Shaik Alaudin. (2018). Chemical composition and antimicrobial efficacy of Helminthostachys zeylanica against foodborne Bacillus cereus. Natural Product Sciences, 24(1), 66-70.
  1. Ainur-Assyakirin Mohd-Sahiba, Jun-Wei Lim, Man-Kee Lam, Yoshimitsu Uemura, Chii-Dong Ho, Wen-Da Oh and Wen-Nee Tan. (2018). Mechanistic kinetic models describing impact of early attachment between Chlorella vulgaris and polyurethane foam material in fluidized bed bioreactor on lipid for biodiesel production. Algal Research, 33, 209-217.
  1. Leong Chean Ring, Tong Woei Yenn, Najwa Izzati binti Nazri, Tan Wen Nee, Khairul Azly Zahan, Darah Ibrahim and Syarifah Rashid. (2018). Chemical optimization of red pigment, monascorubin production in Penicillium minioluteum ED24 using solid-state fermentation. Arabian Journal for Science and Engineering, 43(7), 3485-3491.
  1. Nur Amiera Syuhada Rozman, Tong Woei Yenn, Wen-Nee Tan, Leong Chean Ring, Fahmi Asyadi bin Md Yusof and Baharuddin Sulaiman. (2018). Homalomena pineodora, a novel essential oil bearing plant and its antimicrobial activity against diabetic wound pathogens. Journal of Essential Oil Bearing Plants, 21(4), 963-971.
  1. Kooi-Yeong Khaw, Vikneswaran Murugaiyah, Melati Khairuddean and Wen-Nee Tan. (2018). Garcinexanthone G, a selective butyrylcholinesterase inhibitor from the stem bark of Garcinia atroviridis. Natural Product Sciences, 24(2), 88-92.
  1. Wen-Nee Tan, Woei Yenn Tong, Chean Ring Leong, Nor Faizzah Md Hanafiah, Nur Sufina Ridzuan, Nur Amiera Syuhada Rozman and Sharifah Soplah Syed Abdullah. (2018). Chemical compositions and in vitro antimicrobial activity of Cymbopogon nardus on food borne microorganisms. Malaysian Journal of Microbiology, 14(7), 699-704.
  1. Nurhanis Syafiqah Binti Mohd Nor Hamin, Muhammad Yusoff Sahadan, Nur Amiera Syuhada Rozman, Tan Wen Nee, Tong Woei Yenn, Khairul Azly Zahan, Wahidin Suzana and Leong Chean Ring. (2019). Development of medical cotton fabrics with Punica granatum L extract finishing for nosocomial infections control. Journal of Natural Fibers, 16(3), 404-411.
  1. Muhammad Yusoff Bin Sahadan, Woei Yenn Tong, Wen Nee Tan, Chean Ring Leong, Mohamad Najib Bin Misri, Murphy Chan, See Yuan Cheng and Shahrulzaman Shaharuddin. (2019). Phomopsidione nanoparticles coated contact lenses reduce microbial keratitis causing pathogens. Experimental Eye Research, 178, 10-14.
  1. Tan Wen Nee, Leong Chean Ring, Venoth Arumugam, Judy Loo Ching Yee, Lee Wing Hin, Fahmi Asyadi Md Yusof, Mohd Azizan Mohd Noor and Tong Woei Yenn. (2019). Sustained release geraniol nanoparticles inhibit human axillary odor-causing bacteria. Arabian Journal for Science and Engineering, 44(1), 103-109.
  1. Siti-Suhailah Rosli, Jun-Wei Lim, Khairulazhar Jumbri, Man-Kee Lam, Yoshimitsu Uemura, Chii-Dong Ho, Wen-Nee Tan, Chin-Kui Cheng and Wan-Nadiah-Amalina Kadir. (2019). Modeling to enhance attached microalgal biomass growth onto fluidized beds packed in nutrients-rich wastewater whilst simultaneously biofixing CO2 into lipid for biodiesel production. Energy Conversion and Management, 185, 1-10.
  1. Wen-Nee Tan, Zi-Hui Tan, Nurul Izzati Zulkifli, Nik Nur Syazni Nik Mohamed Kamal, Nur Amiera Syuhada Rozman, Woei-Yenn Tong, Chean-Ring Leong and Jun-Wei Lim. (2019). Sesquiterpenes rich essential oil from Garcinia celebica L. and its cytotoxic and antimicrobial activities. Natural Product Research, In Press. DOI: https://doi.org/10.1080/14786419.2019.1569012
  1. Wen-Nee Tan, Melati Khairuddean, Kooi-Yeong Khaw, Vikneswaran Murugaiyah, Woei Yenn Tong, Chean Ring Leong and Darah Ibrahim. (2019). Phytochemical screening and biological evaluations of Garcinia atroviridis. Iranian Journal of Pharmaceutical Sciences, 15(2), 91-104.
  1. Leong Chean Ring, Tong Woei Yenn, Suzana Wahidin, Wen-Nee Tan, Siti Zubaidah Binti Abdullah, Nurul Aisyah Mohd Jamil and Muhammad Sharir Abdul Rahman. (2019). Antimicrobial wound dressing film utilizing nano-cellulose and gelatin as drug delivery system for Garcinia mangostana L extract. Malaysian Journal of Microbiology, 15(5), 373-378.
  1. Hanan Kumar Gopalan, Nor Faizzah Md Hanafiah, Leong Chean Ring, Wen-Nee Tan, Suzana Wahidin, Teo Siew Hway, and Tong Woei Yenn. (2019). Chemical composition and antimicrobial efficiency of Swietenia macrophylla seed extract on clinical wound pathogens. Natural Product Sciences, 25(1), 38-43.
  1. Wen-Nee Tan, Farah Nabilah Shahbudin, Nik Nur Syazni Nik Mohamed Kamal, Woei-Yenn Tong, Chean-Ring Leong and Jun-Wei Lim. (2019). Volatile constituents of the leaf essential oil of Crinum asiaticum and their antimicrobial and cytotoxic activities. Journal of Essential Oil Bearing Plants, 22(4), 947-954.
  1. Nur Amiera Syuhada Rozman, Tong Woei Yenn, Leong Chean Ring, Tan Wen Nee, Muhammad Ariff Hasanolbasori and Siti Zubaidah Abdullah. (2019). Potential antimicrobial applications of chitosan nanoparticles (ChNP). Journal of Microbiology and Biotechnology, 29(7), 1009-1013.
  1. Wan Nurain FarahahWan Basri, Hanita Daud, Man Kee Lam, Chin Kui Cheng, Wen Da Oh, Wen Nee Tan, Maizatul Shima Shaharun, Yin Fong Yeong, Ujang Paman, Katsuki Kusakabe, Evizal Abdul Kadir, Pau Loke Show and Jun Wei Lim. (2019). A sugarcane-bagasse-based adsorbent employed for mitigating eutrophication threats and producing biodiesel simultaneously. Processes, 7, 572.
  1. Chung Yiin Wong, Jun Wei Lim, Fai Kait Chong, Man Kee Lam, Yoshimitsu Uemura, Wen Nee Tan, Mohammed J.K. Bashir, Sze Mun Lam, Jin Chung Sin and Su Shiung Lam. (2020). Valorization of exo-microbial fermented coconut endosperm waste by black soldier fly larvae for simultaneous biodiesel and protein productions. Environmental Research, 185, 109458.
  1. Nur Amiera Syuhada Rozman, Woei Yenn Tong, Chean Ring Leong, Mohd Razealy Anuar, Sabrina Karim, Siew Kooi Ong, Fahmi Asyadi Md Yusof, Wen-Nee Tan, Baharuddin Sulaiman, Mei Lee Ooi and Kok Chang Lee. (2020). Homalomena pineodora essential oil nanoparticle inhibits diabetic wound pathogens. Scientific Reports, 10, 3307.
  1. Ihsan bin Idris Chin, Tong Woei Yenn, Leong Chean Ring, Yusriah Lazim, Wen-Nee Tan, Syarifah Ab Rashid, Cheng See Yuan, Zaida Rahayu Yet, Siti Zubaidah Abdullah and Md Abu Taher. (2020). Phomopsidione-loaded chitosan polyethylene glycol (PEG) nanocomposite dressing for pressure ulcers. Journal of Pharmaceutical Sciences, https://doi.org/10.1016/j.xphs.2020.06.005
  1. Leong Chean Ring, Tong Woei Yenn, Tan Wen Nee, Nurhanis Syafiqah Mohd nor Hamin, Cheng See Yuan, Sharwan Raziqin Suboh, Nurul Faezawaty Jamaludin, and Nur Izlin Jannah Mubin. (2020). Antimicrobial evaluation of Parkia speciosa-coated textile in food processing settings. Journal of Natural Fibers, https://doi.org/10.1080/15440478.2020.1758278
  1. Syarifah Ab Rashid, Woei Yenn Tong, Chean Ring Leong, Nur Marsya Abdul Ghazali, Md Abu Taher, Noriza Ahmad, Wen‑Nee Tan and Siew Hway Teo. (2020). Anthocyanin microcapsule from Clitoria ternatea: Potential bio‑preservative and blue colorant for baked food products. Arabian Journal for Science and Engineering, https://doi.org/10.1007/s13369-020-04716-y


Book Chapters:

  1. Jun-Wei Lim, Kwok-Yii Leong, Mohammed J.K. Bashir, Wen-Nee Tan, Chandra Mohan Sinnathambi, Man-Kee Lam and Thiam-Leng Chew. (2015). Competitive adsorption of phenol and 4-CP. Contemporary of Sciences Physics, Chemistry and Mathematics, UTP Press, 139.



  • JIK 101 General Chemistry I
  • JIK 322 Organic Chemistry II
  • JIK 327 Chemical Spectroscopy
  • JIK 401 Research Methods in Chemistry and Seminar
  • JIK 422 Organic Chemistry III
  • JIK 502 Special Topics in Organic and Inorganic Chemistry
  • JIK 590 Project
  • KUE 409 Final Year Project



  1. Benedict Anak Samling, 2019-Present, Master (Research), Main Supervisor.
  2. Kashvintha Nagarajan, 2019-Present, Master (Research), Main Supervisor.
  3. Zolkifli Osman, 2019-Present, Master (Research), Main Supervisor.
  4. Tan Ai Fein Ching Ga, 2018-Present, Master (Research), Co-supervisor
  5. Nurul Izzati Binti Zulkifli, 2017-Present, Master (Research), Co-Supervisor.
  6. Md Abu Taher, 2017-Present, PhD, Co-Supervisor.


  1. Bebe Syakinah Binti Hashim, Master (Mixed Mode), Co-Supervisor, Graduated (2017).
  2. Alaa Taha Yasir Al Kanan, Master (Mixed Mode), Co-Supervisor, Graduated (2019).
  3. Nur Amiera Syuhada Rozman, Master (Research), Co-Supervisor, Graduated (2019).


Academic Recognition and Leadership:

  • Visiting Fellow, National Yang-Ming University, 01/10/2019-31/12/2019
  • Course Coordinator, Occupational Safety & Health, School of Distance Education, Universiti Sains Malaysia, 01//01/2018-31/12/2020
  • Assistant Treasurer, Chemistry Alumni Association, Universiti Sains Malaysia, 30/03/2016-31/12/2018
  • Invited Speaker, Introduction to bioactive compounds in medicinal herbs, Workshop on screening for bioactive compound in medicinal herbs using HPTLC, Advanced Medical and Dental Institute (AMDI), Universiti Sains Malaysia, 18-19 October, 2016

Achievements and Awards:

  • Taiwan Fellowship, Republic of China (Taiwan), 2019
  • Travel Grant, Novo Nordisk Foundation, Denmark, 2019
  • USM Hall of Fame Prize (Journal Publication), Universiti Sains Malaysia, 2018
  • USM Hall of Fame Prize (Journal Publication), Universiti Sains Malaysia, 2017
  • USM Hall of Fame Award (Journal Publication), Universiti Sains Malaysia, 2017
  • Excellent Service Award, Universiti Sains Malaysia, 2017

Research Grants: (Principal Investigator)

  • Volatile and non-volatile constituents and biological activities on Garcinia atroviridis. USM Short Term Grant, RM39,739.20, 15/09/2015-15/03/2018. Completed
  • Studies of Cynometra cauliflora essential oils and nanoencapsulation against cytotoxic activity . USM Short Term Grant, RM30,844.20, 15/01/2019-14/04/2021. On-going
  • Determination of modulatory mechanism of rosmarinic acid on the biosynthesis of a novel antibiotic Phomopsidione by endophytic Diaporthe fraxini ED2 via metabolomics study. Fundamental Research Grant Scheme (FRGS), RM120,000.00, 01/01/2019-31/03/2022. On-going

Research Grants: (Co-Researcher)

  • Understanding the mechanisms of actions of Caudatus plant extracts on cancer metabolism of HepG2 and AML12 human liver cell lines. Research University (Individual) Grant (RUI), RM100,000.00, 01/03/2016-28/02/2018. Completed
  • Pharmacological effects and antibiotic mechanism of a new compound Phomopsidione on extensively drug resistant Pseudomonas aeruginosa. Fundamental Research Grant Scheme (FRGS), RM105,700, 03/07/2017-31/12/2019. Completed
  • The modulatory effects of biogenic nanoparticles on cytogenetic of extrachromomal DNA and their interactions with the DNA damage checkpoint and repair foci regulatory molecules in both cancerous and non-cancerous human lung cells at the molecular level. Fundamental Research Grant Scheme (FRGS), RM87,900, 15/08/2017-14/11/2020. On-going
  • Pre-clinical evaluation of the novel antibiotic Phomopsidione in Pseudomonas aeruginosa pneumonia animal models. Prototype Development Reseach Grant Scheme (PRGS), RM150,000.00, 01/09/2019-31/08/2021. On-going

Professional Affiliation/Membership:

  • Member, Royal Society of Chemistry (MRSC), United Kingdom, since 2018
  • Member, Malaysian Institute of Chemistry (MMIC), Malaysia, since 2017
  • Member, Malaysian Natural Products Society (MNPS), Malaysia, since 2017